Polywell 4U4GPU12N-E5: Advanced AMD EPYC GPU Server from an SFF Market Leader
Polywell Computers — already recognized as one of the global leaders in industrial-grade Small Form Factor (SFF) PCs — is now rapidly advancing in the enterprise server market. The new 4U4GPU12N-E5 is the clearest demonstration of this evolution: a high-performance, multi-GPU, AMD EPYC–powered server designed for AI, HPC, cloud workloads, and next-generation data processing at scale.
With cutting-edge EPYC architecture, ultra-high memory bandwidth, and support for up to four full-length double-width GPUs, this system positions Polywell Computers among the most technically advanced server builders in the industry.
Why the 4U4GPU12N-E5 Redefines EPYC GPU Compute
The 4U4GPU12N-E5 brings together AMD’s leadership in server CPUs with Polywell’s expertise in building reliable, high-density systems for mission-critical 24/7 environments.
Extreme EPYC Performance for AI, Cloud & HPC
Powered by the AMD EPYC 7003/7002 series (Rome / Milan) with:
- Up to 64 cores per CPU
- Exceptional I/O bandwidth
- Industry-leading PCIe lanes
- Superior memory performance
The platform is engineered for:
- Deep learning training & inferencing
- HPC simulations
- Data analytics & large datasets
- Virtualization and VDI
- Supports Up to 4 High-End GPUs
The 4U form factor is optimized for GPU density:
- Up to four double-width GPUs
- Compatible with NVIDIA, AMD Instinct, and other accelerators
- Ideal for AI frameworks, CUDA workloads, ML pipelines, rendering, and parallel compute
This makes the 4U4GPU12N-E5 an excellent choice for organizations building AI/ML clusters.
- 16 DIMMs & Massive Memory Bandwidth
With 16 DDR4 ECC Registered DIMM slots, the system supports:
- Large in-memory databases
- Real-time analytics
- Memory-intensive virtualized environments
- Big data frameworks
- High-Capacity Storage for Large Workloads
The system provides exceptional scalability:
- Up to 12 hot-swap 3.5″/2.5″ SATA/SAS bays
- Support for NVMe SSDs
- Hardware RAID options
- Excellent airflow for multi-disk configurations
Perfect for large datasets, AI training libraries, VFX assets, or HPC scratch storage.
- Advanced Networking & Expansion
Built for modern data-center networking:
- Dual LAN + flexible high-speed NIC options
- PCIe Gen4 lanes for NICs, accelerators, and storage controllers
- Full IPMI remote management
Designed for cloud deployments, multiserver clusters, and mission-critical enterprise environments.
Engineered for 24/7 Operation
Polywell applies its industrial DNA to high-performance server design:
- Redundant 80 PLUS Platinum PSUs
- Optimized airflow for four-GPU configurations
- Tool-less service and hot-swap components
- Certified for long-term continuous operation
This is a server built to run non-stop.
Who Needs the Polywell 4U4GPU12N-E5?
Ideal for organizations requiring massive parallel compute and top-tier reliability:
- AI / Deep Learning
Training LLMs, CV/ML workloads, TensorFlow/PyTorch pipelines.
- HPC & Scientific Computing
Engineering, simulations, modeling, and research workloads.
- Data Analytics & Enterprise Workloads
Big data clusters, distributed environments, high-density processing.
- Cloud & Virtualization Platforms
Private cloud environments, multi-tenant virtualization, VDI.
- Media, Rendering & VFX
4K/8K production pipelines, GPU-accelerated rendering, encoding/transcoding.
Polywell’s Evolution: From SFF Excellence to Advanced Server Manufacturing
Polywell Computers has earned global recognition as a leading manufacturer of industrial-grade SFF systems — rugged, reliable, and deployed worldwide in mission-critical applications.
Today, Polywell is expanding this expertise into enterprise-class servers, offering:
- Advanced Intel Xeon and AMD EPYC server platforms
- High-density GPU compute nodes
- HPC-ready multi-CPU systems
- Rackmount platforms for cloud & AI
- Customized hardware for enterprise deployments
This strategic move places Polywell among the most advanced and agile server developers in the market.
Discover More & Experience Polywell’s Next-Gen Servers
- Explore Full Specs & Configurations
- Request a Custom Quote
You may also want to have a look at our other new products:
H810AEL2 – Polywell Computers EMEA
JSON-THOR3M – Polywell Computers EMEA
JSON-THOR3L – Polywell Computers EMEA
Nano-U12FL2+4PoE – Polywell Computers EMEA
Q870AEL2 – Polywell Computers EMEA
Nano-UC14L2V3c – eu.polywell.com
Nano-N100L2C2 – eu.polywell.com
i2319-RTX5070 – eu.polywell.com
The previous news releases may be found here.
About Polywell Computers Polywell Computers (since 1987) is a Silicon Valley based trusted manufacturer of SFF industrial-grade and embedded computers tailored for a wide range of applications. Being positive that the two major trends in modern digitalization process are reduction of size and power consumption of PCs and their usage in vast range of business applications, we have focused on design and manufacture of mini-PCs and servers assembled with industrial grade components.
The company has built its reputation by becoming a recognized leader in the PC market and is widely known not only in the U.S., but also in Europe, Latin America, and Asia. Our systems are marked with the signs of excellence in major IT media on a regular basis.